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KMID : 0357119980200040451
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Korean Journal of Immunology
1998 Volume.20 No. 4 p.451 ~ p.457
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The Clinical Significance of IgG Antibodies to Native Human Type Ⅱ Collagen in Patients with Rheumatoid Arthritis
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김호연/Wan-Hee Yoo
Wan-Uk Kim/Sung-IL Kim/Jeehee Youn/Suk Kyeong Lee/Young-Shil Joo/Jae-Ho Park/Shin-Seok Lee/Jun-Ki Min/Yeon-Sik Hong/Sang-Heon Lee/Sung-Hwan Park/Chul-Soo Cho/Ho-Youn KIm
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Abstract
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Objective: To determine the clinical significance of IgG antibodies to native type II collagen (IgG nCII) in patients with rheumatoid arthritis (RA).
Methods: IgG antibodies to native type II collagen (anti-HnCII) were measured in 287 patients with RA, 34 patients with osteoarthritis (OA) and 50 normal controls by improved ELISA using avidin-biotin system and 100% normal goat serum. The clinical and laboratory variables were investigated in patients with RA at the time of sampling.
Results: The titers of anti-HnCII were higher in RA than OA and normal control (median value 5.2 in RA, 3.0 in OA, 1.7 a.u in normal) (p<0.05). The incidence of anti-HnCII positivity was also higher in RA than OA (39.1% vs. 17.6%) (p<0.05). In 218 evaluable patients, 98 patients with anti-HnCII positive had higher levels of ESR (p<0.001) and CRP (p<0.001) than 120 patients with anti-HnCII negative. The titers of anti-HnCII was also closely correlated with CRP (r=0.385) and ESR (r=0.235). However, no differences were found in titers of rheurnatoid factor, positivity of rheumatoid factor and hemogiobin levels. Incidence of anti-HnCII positivity was not related to disease duration (31/59 in <3 year, 63/148 in >3 year). There was no differences in age, sex, erosions on X-ray, mean steroid dose, use of DMARD, extraarticular manifetations such as lung involvement, rheumatoid nodule, Sjogren's syndrome between groups with anti-HnCII positive and negative. However, deformity was more frequently found in anti-HnCII negative (p<0.05). Among the 83 patients measured anti-HnCII serially (mean interval; 15+-6 month), 11 of 24 patients with anti- HnCII positve (45.8%) were converted to negative and 19 of 59 patients with anti- HnCII negative (32.2%) were converted to positive. The levels of CRP decreased in groups converted from positive to negative (p<0.05) and vice versa (p<0.05).
Conclusion: These results suggest that the levels of IgG HnCII fluctuate with positive correlation with acute phase reactants and may reflect the inflammatory activity of RA.
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KEYWORD
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Antibodies to human native type II collagen, Rheumatoid arthritis, Disease activity,
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